Importance of the First Design Matrix in Experimental Simplex Optimization
نویسنده
چکیده
During the last decades a number of studies on modifications and improvement of the original algorithm have been published. The first design matrix is however one aspect of simplex optimization that has raised substantially less interest, despite the observation of its importance for the speed of convergence by Nelder and Mead. This is probably due to the fact that Spendley et al already in their first presentation of the sequential simplex method were unable to show any consistent or major effect of orientation. Walters et al have likewise not been able to show any practical advantages of the tilted first simplex, suggested by Spendley et al, as compared to a cornered first simplex (a first-order Koshal design).
منابع مشابه
Floating Matrix Tablets of Domperidone Formulation and Optimization Using Simplex Lattice Design
The purpose of this research was to prepare a floating matrix tablet containing domperidone as a model drug. Polyethylene oxide (PEO) and hydroxypropyl methylcellulose (HPMC) were evaluated for matrix-forming properties. A simplex lattice design was applied to systemically optimize the drug release profile. The amounts of PEO WSR 303, HPMC K15M and sodium bicarbonate were selected as independen...
متن کاملFloating Matrix Tablets of Domperidone Formulation and Optimization Using Simplex Lattice Design
The purpose of this research was to prepare a floating matrix tablet containing domperidone as a model drug. Polyethylene oxide (PEO) and hydroxypropyl methylcellulose (HPMC) were evaluated for matrix-forming properties. A simplex lattice design was applied to systemically optimize the drug release profile. The amounts of PEO WSR 303, HPMC K15M and sodium bicarbonate were selected as independen...
متن کاملDevelopment and Optimization of Ferrous Fumarate Chewable Tablets by Simplex Experimental Design
Chewable ferrous fumarate tablet is the best iron dosage form for children due to better compliance and lower teeth staining compared to the oral drop. Because of the different desirable properties of chewable tablets and the opposing effects of fillers on them, the mathematical experimental design was used as the formulation approach. Different series of formulations based on single filler (La...
متن کاملDamped DQE Model Updating of a Three-Story Frame Using Experimental Data
In this paper, following a two-stage methodology, the differential quadrature element (DQE) model of a three-story frame structure is updated for the vibration analysis. In the first stage, the mass and stiffness matrices are updated using the experimental natural frequencies. Then, having the updated mass and stiffness matrices, the structural damping matrix is updated to minimize the error be...
متن کاملFixture Design and Work Piece Deformation Optimization Using the Iterative Simplex Algorithm
Presents article is deal with optimization of the fixture for end milling process, the most important objective being the minimization of work piece deformation by changing the layout of fixture elements and the clamping forces. The main objective of this work has been the optimization of the fixtures Work piece deformation subjected to clamping forces for End milling operation. The present ana...
متن کامل